Circadian Rhythms in Neurospora crassa: Biochemistry and Genetics
Critical Reviews in MicrobiologyPublished 1 January 1990
Patricia L. Lakin‐Thomas, Gary G. Coté, Stuart Brody
Citations134
SJR quartileQ1
SJR score1.82
SNIP1.78
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Abstract
(1990). Circadian Rhythms in Neurospora crassa: Biochemistry and Genetics. Critical Reviews in Microbiology: Vol. 17, No. 5, pp. 365-416.
Keywords
Biochemistry, Genetics and Molecular BiologyAgricultural and Biological SciencesEnergy
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The acyl-carrier protein (ACP) in Neurospora crassa mitochondria mediated a cerulenin-sensitive, de novo fatty acid synthesis independent of the fatty acid synthetase complex present in the cytoplasm.
PLANT PHYSIOLOGYEffects of Temperature Perturbations on Circadian Conidiation in <i>Neurospora</i>
80 Citations1979Cynthia D. Francis, Malcolm Sargent
Small amplitude temperature cycles are capable of entraining the circadian rhythm, and holding bd at low temperatures appears to stop the circadian oscillator late in the subjective night (circadian time 2200).
ScienceAdenylate Cyclase Activation Shifts the Phase of a Circadian Pacemaker
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Results show that adenosine 3',5'-monophosphate mediates the effect of serotonin on the rhythm and regulates the phase of the circadian pacemaker in the eye of Aplysia.
GeneticsA RECESSIVE CIRCADIAN CLOCK MUTATION AT THE <i>frq</i> LOCUS OF <i>NEUROSPORA CRASSA</i>
79 Citations1986Jennifer Loros, Adam Richman +1 more
The recessive nature of frq-9, coupled with complete loss of temperature compensation, suggests that this mutant may represent the null phenotype of the locus and that the frq gene is involved in the temperature compensation mechanism of the clock.
GeneticsTHE <i>frq</i> LOCUS IN <i>NEUROSPORA CRASSA</i>: A KEY ELEMENT IN CIRCADIAN CLOCK ORGANIZATION
77 Citations1980George F. Gardner, Jerry F. Feldman
Four new circadian clock mutants of Neurospora crassa have been isolated that alter the period length of the circadian conidiation rhythm, three of these are at the frq locus on linkage group VIIR, where four other clock mutants are located.
Journal of BacteriologyGenetic Determinants of Circadian Rhythmicity in <i>Neurospora</i>
75 Citations1969Malcolm Sargent, Dow O. Woodward
Timex, a strain of Neurospora crassa which exhibits a circadian rhythm of conidia formation in growth-tube cultures, has been found to differ from wild-type strains by two genes, one of which is responsible for an invertase deficiency, whereas the second gene is of unknown function.
Journal of BacteriologyCircadian rhythms in Neurospora crassa: effects of unsaturated fatty acids
72 Citations1979Stuart Brody, Sara Martins
Employing a fatty acid-requiring strain (bd csp cel) of Neurospora crassa, the 21.5-h period of the circadian spore-forming rhythm was manipulated by fatty acid supplementation, which lengthened the period to 26, 40, or 33 h, respectively.
Proceedings of the National Academy of SciencesPhotoreception in Neurospora crassa: correlation of reduced light sensitivity with flavin deficiency.
72 Citations1981John V. Paietta, Malcolm Sargent
Evidence is provided that one or more flavin photoreceptors are involved in the blue light responses of Neurospora, and that the effects on light sensitivity were due solely to the presence of the rib mutations.
Proceedings of the National Academy of SciencesActive transport of calcium in Neurospora plasma membrane vesicles.
67 Citations1979Paul Stroobant, Gene A. Scarborough
Comparisons of Mg2+/ATP-driven 45Ca2+ uptake and [14C]SCN-uptake and the effects of inhibitors, and the nucleotide and divalent cation specificities indicate that the energy for Ca2+ accumulation is derived from ATP hydrolysis catalyzed by the electrogenic plasma membrane ATPase.
Science<i>Neurospora</i> Circadian Rhythms in Space: a Reexamination of the Endogenous-Exogenous Question
67 Citations1984Frank M. Sulzman, David Ellman +3 more
At the current stage of analysis of results, there is insufficient evidence to determine whether the effect seen in space was related to removal from 24-hour periodicities and whether the circadian timekeeping mechanism, or merely its expression, was affected.
ScienceCircadian Periodicity in <i>Neurospora</i> : Alteration by Inhibitors of Cyclic AMP Phosphodiesterase
65 Citations1975Jerry F. Feldman
Three methyl xanthine inhibitors of adenosine 3',5'-monophosphate phosphodiesterase-theophylline, aminophyline, and caffeine-lengthen the period of the circadian conidiation rhythm of Neurospora.
Proceedings of the National Academy of SciencesOn the role of protein synthesis in the circadian clock of Neurospora crassa.
65 Citations1988Jay Dunlap, Jerry F. Feldman
It is suggested that for normal operation of the Neurospora clock, certain protein(s) with a high turnover rate are required daily and, thus, must be resynthesized each day (at least) during discrete times in the cycle.
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64 Citations1979Subhuti Dharmananda, Jerry F. Feldman
The presence of a functional circadian clock not only at the growing front but in all other regions of the culture as well was demonstrated and the entire culture is not in the same phase, but shows a gradient of phases which is a function of the length of time the clock in a given part of theculture has been free-running.
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64 Citations1982Daniell L. Mattern, Linda Forman +1 more
Cel displayed a threshold temperature or "break point" for the temperature compensation of its rhythm, and Supplementation of cel strains, which require fatty acids, with unsaturated or short-chain fatty acids raised the threshold temperature to 26 degrees C, whereas supplementation with long-chain saturated fatty acids lowered it to 18 degrees C.
GeneticsPHASE-SPECIFIC GENES FOR MACROCONIDIATION IN <i>NEUROSPORA CRASSA</i>
64 Citations1974Claude P. Selitrennikoff, Robert E. Nelson +1 more
Two new mutant genes in Neurospora crassa prevent the formation of free macroconidia from proconidial chains, suggesting that the products of these genes are both essential for and unique to macroconidiation.
Physiologia PlantarumGrowth synchrony and cellular parameters of the unicellular nitrogen‐fixing marine cyanobacterium, <i>Synechococcus</i> sp. strain Miami BG 043511 under continuous illumination
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Data indicate that this unicellular cyanobacterium can grow diazotrophically under conditions of continuous illumination by the segregation of photosynthesis and nitrogen fixation within a cell division cycle.
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The autosomal complement was screened for loci that show a dosage-dependent interaction with mutations in previously characterized genes thought to be important in the determination of segment identity and twelve regions were identified that when present in three wild-type copies strongly enhanced or suppressed the phenotype of mutations at one of the four homoeotic loci examined.
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Eight nuclear mutants that are defective in splicing the mitochondrial large ribosomal RNA and that accumulate unspliced precursor RNA are identified, suggesting that at least one component required for mitochondrial RNA splicing is regulated such that its synthesis or activity is increased in response to impairment of electron transport.
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ScienceCircadian Rhythms in <i>Neurospora</i> : Spatial Differences in Pyridine Nucleotide Levels
54 Citations1973Stuart Brody, Stephanie A. Harris
Journal of Theoretical BiologyCircadian rhythms in Drosophila melanogaster: Analysis of period as a function of gene dosage at the per(period) locus
54 Citations1986Gary G. Coté, Stuart Brody
Three possible roles for the per gene product in circadian rhythmicity are discussed, including a role in synchronizing rhythm-producing cells and an explanation for the partial dominance of pers over per+ and the dominance of per+ over per1.
Photochemistry and PhotobiologyCORRELATION BETWEEN ABSORBANCE CHANGES AND A PHYSIOLOGICAL RESPONSE INDUCED BY BLUE LIGHT IN <i>NEUROSPORA</i>
54 Citations1978Eva Klemm, Helga Ninnemann
Evidence is presented for their causal relationship with the perception of light which induced conidia formation under conditions of starvation in Neurospora crassa mutant albino band, but not with light‐induced phase shifts of conidiation bands.
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid MetabolismEffects of temperature acclimation on Neurospora phospholipids Fatty acid desaturation appears to be a key element in modifying phospholepid fluid properties
51 Citations1981Charles E. Martin, Devora Siegel +1 more
The data are consistent with the idea that phospholipid composition in Neurospora is under strict control and suggest that membrane fluidity is regulated with respect to growth temperature through changes in membrane lipid composition.
Biochemical and Biophysical Research CommunicationsPhotoreceptor pigment for blue light responses in Neurospora crassa
50 Citations1974Víctor Sierra Muñoz, Stuart Brody +1 more
The action spectrum for the photoreduction of the cytochrome b is similar to action spectra for the photoactivation of carotene synthesis and photoinhibition of the circadian rhythm of conidiation in Neurospora.
GeneticsCIRCADIAN RHYTHMS IN <i>NEUROSPORA CRASSA</i>: INTERACTIONS BETWEEN CLOCK MUTATIONS
50 Citations1985Patricia L. Lakin‐Thomas, Stuart Brody
In the series of cel frq double mutant strains, the period-lengthening effect of 18:2 is inversely proportional to the period of the frq parent, indicating an interaction between frq and cel.
GeneticsGENETIC AND PHYSIOLOGICAL CHARACTERISTICS OF A SLOW-GROWING CIRCADIAN CLOCK MUTANT OF <i>NEUROSPORA CRASSA</i>
49 Citations1978Jerry F. Feldman, Cheryl A Atkinson
A circadian clock mutant of Neurospora crassa with a period length of about 25.8 hours (4 hr longer than wild type) has been isolated after mutagenesis of the band strain, and it is recessive in heterokaryons and grows at about 60% the rate of the parent band strain on both minimal and complete media.
BiochemistryCircadian rhythms in Neurospora crassa: oscillations in fatty acids
49 Citations1982Phoebe E. Roeder, Malcolm Sargent +1 more
Biochemical and Biophysical Research CommunicationsThe elongation of medium chain trienoic acids to α-linolenic acid by a spinach chloroplast stroma system
48 Citations1973Bruce S. Jacobson, C. Gamini Kannangara +1 more
An enzyme system present in the stromal fraction of spinach chloroplasts specifically elongated medium chain trienoic fatty acids to α-linolenic acid with either acetyl or malonyl CoA, fulfilling an essential requirement for the proposed two pathway systems for polyunsaturation in plants.
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