Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions
NeurosciencePublished 1 January 1991
M.T. Bardo, Ronald P. Hammer
Citations3,233
SJR quartileQ2
SJR score1.01
SNIP0.76
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TL;DR
The densities of D1 and D2 receptors in the brain are resistant to differential rearing conditions and are compared in groups of animals raised from 30 to 60 days of age in an impoverished condition, a group-caged condition or an enriched condition.
Abstract
These findings indicate that limbic activation is one component of cue-induced cocaine craving. Limbic activation may be similarly involved in appetitive craving for other drugs and for natural rewards.
Keywords
MedicineNeuroscience
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The densities of D1 and D2 receptors in the brain are resistant to differential rearing conditions and are compared in groups of animals raised from 30 to 60 days of age in an impoverished condition, a group-caged condition or an enriched condition.
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Little information has accumulated to indicate by what mechanism the emotions can so act on autonomic centers as to lead to diseases as diverse as essential hypertension, peptic ulcer, asthma, etc.
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Journal of NeurophysiologyReward Value Coding Distinct From Risk Attitude-Related Uncertainty Coding in Human Reward Systems
480 Citations2006Philippe N. Tobler, John P. O’Doherty +2 more
Functional magnetic resonance imaging was used to identify brain activations coding the key decision parameters of expected value and uncertainty separately from uncertainty of monetary rewards, demonstrating the distinct coding in key reward structures of the two basic and crucial decision parameters, expected value, and uncertainty.
ScienceCholinergic Interneurons Control Local Circuit Activity and Cocaine Conditioning
467 Citations2010Ilana B. Witten, Shih-Chun Lin +7 more
These neurons could be activated by cocaine, and silencing this drug-induced activity during cocaine exposure (despite the fact that the manipulation of the cholinergic interneurons was not aversive by itself) blocked cocaine conditioning in freely moving mammals.
Journal of NeurophysiologyAnatomy of Motor Learning. II. Subcortical Structures and Learning by Trial and Error
466 Citations1997M. Jueptner, Chris Frith +3 more
It is tentatively suggested that the basal ganglia may be involved in the specification of movement on the basis of memory of either the movements or the outcomes, but that the cerebellum may be more directly involved in changes in the parameters of movement execution.
NeuroscienceOrganization of amygdaloid projections to the prefrontal cortex and associated striatum in the rat
460 Citations1991Alexander J. McDonald
Findings indicate that discrete areas of the amygdala, and in some cases individual amygdaloid neurons, can modulate information processing in the first two links of distinct cortico-striato-pallidal systems arising in the medial and lateral prefrontal cortex.
Neuroscience & Biobehavioral ReviewsLimbic-striatal interactions in reward-related processes
458 Citations1989Trevor W. Robbins, Martine Cador +2 more
Experiments using explicit conditional visuo-spatial discrimination tasks suggest that similar discriminative properties are preserved following DA depletion from the ventral, but not the dorsal, striatum, which possibly represents a dissociation between stimulus-response and stimulus-reward associative mechanisms.
American Journal of PsychiatryChanges in brain glucose metabolism in cocaine dependence and withdrawal
458 Citations1991Nora D. Volkow, Joanna S. Fowler +6 more
The selectivity of changes in glucose metabolism for the basal ganglia and for the orbitofrontal cortex suggests that the regional metabolic changes seen in cocaine abusers during detoxification are related to changes in brain dopamine activity.
NeurosciencePharmacological characterization of dopamine systems in the nucleus accumbens core and shell
457 Citations1992Ariel Y. Deutch, D.S. Cameron
There are significant differences between the nucleus accumbens core and nucleus Accumbens shell in basal dopamine metabolism, and this work indicates that the core and shell dopamine innervations can be distinguished on the basis of response to both pharmacological and environmental challenges.
NeuroscienceOrganization of the output of the ventral striatopallidal system in the rat: Ventral pallidal efferents
456 Citations1993H.J. Groenewegen, Henk W. Berendse +1 more
The efferent projections of the ventral pallidum in the rat were studied using anterograde tracing of Phaseolus vulgaris-leucoagglutinin and retrograde tracing of choleratoxin subunit B to determine the degree of topographical organization in the outputs of the vents.
ScienceThe Neostriatal Mosaic: Striatal Patch-Matrix Organization Is Related to Cortical Lamination
452 Citations1989Charles R. Gerfen
The results demonstrate that the compartmental organization of corticostriatal inputs is related to their laminar origin and secondarily to the cytoarchitectonic area of origin.
European Journal of NeuroscienceBlockade of NMDA receptors in the dorsomedial striatum prevents action–outcome learning in instrumental conditioning
451 Citations2005Henry H. Yin, Barbara J. Knowlton +1 more
These experiments provide the first direct evidence that, in instrumental conditioning, NMDARs in the dorsomedial striatum are involved in encoding action–outcome associations.
NeuroscienceAnatomical and affinity state comparisons between dopamine D1 and D2 receptors in the rat central nervous system
448 Citations1989Eric K. Richfield, John B. Penney +1 more
The anatomical distributions and affinity states of dopamine D1 and D2 receptors were compared in the rat central nervous system using quantitative autoradiography to provide an anatomical framework for evaluating behavioral and electrophysiological evidence of an interaction between the two dopamine receptor subtypes.
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