Top Research Papers on Diabetes

Advances in genomic analysis are described that have enabled novel genetic discoveries, more than doubled the number of genetic loci associated with type 2 diabetes mellitus and uncovered several novel candidate genes for diabetes complications.

Multi-level factors associated with the presence and the severity of diabetic retinopathy are shown, including education levels, household income, and multiple dietary intakes.

Understanding the precise role of MCs in wound progression and healing processes can be of critical importance as it can lead to the development of new targeted therapies for diabetic foot ulceration, one of the most devastating complications of diabetes.

The types of monogenic diabetes are described, including common and uncommon types of maturity-onset diabetes of the young, multiple causes of neonatal DM, and syndromic diabetes such as Wolfram syndrome and lipodystrophy.

The COVID-19 pandemic and LSSR have impact on diabetes management and diabetes-related complications as assessed by PWD in Indonesia.

Current preclinical models of GDM are discussed to better understand the underlying pathophysiology of the disease and the timely need to increase the scientific toolbox to identify strategies to prevent and treat GDM, thereby advancing clinical care.

This review particularly focuses on novel targets that may play role in pathogenesis of type 2 diabetes and further research on these targets may eventually pave the way to novel therapies for the treatment—or even the prevention— of type 1 diabetes along with its complications.

The effects of quercetin on the key mechanisms of pathogenesis of diabetes complications including nephropathy, cardiovascular complications, neuropathy, delayed wound healing, and retinopathy are reviewed.

The American Diabetes Association (ADA) “Standards of Care in Diabetes” includes the ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recomme...

Clinical applicability of OCTA derived quantitative metrics that appear to be clinically relevant to the diagnosis, classification, and management of patients with diabetes or DR are focused on.

The American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recomme...

The global prevalence of diabetes mellitus has been increasing steadily for over 50 years and has now reached pandemic proportions. The prevalence of both diagnosed and undiagnosed diabetes was estimated to be 9.3% (463 million people) in 2019, and is projected to rise to 10.2% (578 million) by 2030 and 10.9% (700 million) by 2045 [[1]Saeedi P. Petersohn I. Salpea P. Malanda B. Karuranga S. Unwin N. et al.Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas.Diab Res Clin Pract. 2019; 157:...

The American Diabetes Association (ADA) “Standards of Care in Diabetes” includes the ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recomm...

The American Diabetes Association (ADA) “Standards of Care in Diabetes” includes the ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recomm...

A systematic overview of the effects of diabetes on in-stent restenosis is presented, emphasizing the importance of glycemic control in diabetic patients and the main mechanisms underlying the pathophysiology of this event.

Precision medicine approaches are available for some forms of monogenic diabetes (including GCK - and HNF1A -diabetes) and increase patients’ quality of life and next-generation sequencing has made genetic diagnosis affordable, enabling effective genomic medicine in monogenicabetes.

C Cotreatment of obesity and diabetes requires a comprehensive medical approach that encompasses intensive lifestyle modification including behavioral changes, nutrition, and physical activity, as well as pharmacotherapy and possible surgical management.

This Primer by Umpierrez and colleagues reviews the epidemiology, pathophysiology, diagnosis and management of diabetic ketoacidosis, the most common acute hyperglycaemic emergency in people with diabetes mellitus and provides practical recommendations for the management of DKA in adults and children.

This review manuscript summarizes current knowledge on the cellular and molecular pathways involved in diabetic fibrosis, discussing the fundamental links between metabolic perturbations and fibrogenic activation, the basis for organ-specific differences, and the promises and challenges of anti-fibrotic therapies for diabetic patients.

An overview of the literature addressing the association between obesity and T2DM is provided, briefly discussing the pathophysiological mechanisms linking these conditions and outlining the management approach at the overlap of obesity andT2DM.