Top Research Papers on Heterocyclic Compounds PDF

The present report summarizes the construction of four to eight-membered heterocyclic compounds containing nitrogen, oxygen and sulphur atoms through phosphine-catalyzed intramolecular annulations and intermolecular Annulations of electron-deficient alkenes, allenes, alkynes and Morita-Baylis-Hillman carbonates.

The high demand for new and efficient routes toward synthesis of nitrogen-containing heterocyclic scaffolds has inspired organic chem-ists to discover several methodologies over recent years, which involves the use of pyri-dotriazoles and related compounds in denitrogenative transformations.

This review surveys recent progress in the chemistry of polycyclic heteroaromatic molecules with a focus on structural diversity and synthetic methodology, providing an update to the first review of this topic in 2017.

This mini-review explores cytotoxic, cytoprotective, antinociceptive, anti-inflammatory, and antidepressant activities of some pyrazole analogs to advance structure-related pharmacological profiles and rational design of new analogs.

Nitrogen based heterocyclic compounds are extensively used as corrosion inhibitors because of their ability to form strong coordination bonding with the metallic atoms. In the present review article anticorrosive effect of pyridine based compounds is surveyed. Generally, pyridine derivatives with electron withdrawing and electron donating substituents showed higher anticorrosion effect than that of the native pyridine. Pyridine derivatives containing polar substituents at 2nd and 6th positions form highly stable chelating complexes. The mono- (2nd position) and di- (2nd and 6th position) subst...

This review highlights recent pioneering studies in the biological assessment of nitrogen-containing compounds, namely: triazoles, tetrazoles, imidazole/benzimidazols, pyrimidines, and quinolines, which will benefit researchers in medicinal chemistry and pharmacology.

This study examined synthesized some 5- or 6-ring N-heterocyclic compounds that showed the antiviral activity in last 5 years, and investigation of these compounds structure-activity relationship studies will be useful to scientists in research fields of organic synthesis, medicinal chemistry, and pharmacology.

This review aims to bring and discuss the detailed information on the antibacterial activity of various nitrogen-based heterocyclic compounds with nitrogen moiety that will be helpful for the future evolution of diseases to synthesize new and effective drug molecules.

Heterocyclic compounds with excellent nonlinear optical (NLO) properties are highly significant and have many potentials uses in various fields such as nuclear science, optoelectronics etc. Herein, an organic dye JK-201 was used theoretically to design a series of novel D-π-A based NLO molecules (DTA1-DTA12). This novel series of NLO molecules was quantum chemically designed by structural tailoring at the 1st π-spacer and acceptors unit of the JK-201 molecule. To explore the effect of spacers and acceptors on the electronic, photophysical, and NLO properties of DTA1-DTA12, density functional t...

The chemistry of heterocyclic compounds has traditionally been and remains a bright area of chemical science in Russia. This is due to the fact that many heterocycles find the widest application. These compounds are the key structural fragments of most drugs, plant protection agents. Many natural compounds are also derivatives of heterocycles. At present, more than half of the hundreds of millions of known chemical compounds are heterocycles. This collective review is devoted to the achievements of Russian chemists in this field over the last 15–20 years. The review presents the achievements o...

This unconventional transformation is orthogonal to traditional ring contractions, challenging the paradigm for diversification of heterocycles including piperidine, morpholine, thiane, Tetrahydropyran, and tetrahydroisoquinoline derivatives.

Bioinspired heterocyclic organic molecules have high significance as potential substitutes to the existing inhibitor chemistries, which are considered toxic and costly. Here, we provided a detailed review of the different kinds of heterocyclic macrocyclic compounds and biomolecules and their various chemically modified derivatives and composites as corrosion inhibitors. An account of typically used five, and six-membered heterocyclic compounds (basic constituents of biomolecules, drugs, etc.) is also provided. The review starts with a background of the different corrosion issues commonly encou...

Medicinal chemistry continues to be impacted by new synthetic methods. Particularly sought after, especially at the drug discovery stage, is the ability to enact the desired chemical transformations in a concise and chemospecific fashion. To this end, the field of organic synthesis has become captivated by the idea of 'molecular editing'-to rapidly build onto, change or prune molecules one atom at a time using transformations that are mild and selective enough to be employed at the late stages of a synthetic sequence. In this Review, the definition and categorization of a particularly promisin...

Efficient amination strategies for synthesis of N-heterocycles from functional molecules (bottom-up) or from biomass (top-down) via sustainable C–N/C–X bond chemistry.

A versatile method of N-atom excision from N-heterocycles is reported, which proceeds by N-sulfonylazidonation followed by the rearrangement of sulfamoyl azide intermediates, providing various cyclic products.

An overview of N-heterocyclic carbene catalyzed radical reactions via different synthetic techniques is given to provide a conceptual understanding of this emerging area.

A review article summarizes the results obtained with the isolated aNHCs, which successfully accomplished the metal-free catalytic formylation of amides using CO2 and the catalytic reduction of carbon dioxide, including atmospheric CO2, into methanol, under ambient conditions.

This review tries to present a comprehensive overview of top prescribed drugs containing nitrogen heterocycles, describing their pharmacological properties, medical applications and their selected synthetic pathways.

Modifications of different fatty acids with existing anticancer drugs and heterocyclic moieties by condensation reactions increased the tissue selectivity and made chemotherapy potentially more effective and less toxic in in vivo and in vitro studies.

The present article summarizes the recent development of both natural and synthetic spirooxindole-containing compounds prepared from isatin or its derivatives reported in the last five years.