Top Research Papers on Kindle

This work builds a simple yet effective network for Kindling the Darkness (denoted as KinD), which, inspired by Retinex theory, decomposes images into two components that are robust against severe visual defects, and user-friendly to arbitrarily adjust light levels.

Correcting for Slater’s fallacy removed the appearance of decreasing intermorbid intervals for unipolar depression and proposed an alternative model, which showed individuals who are highly recurrent have consistently shorter interMorbid periods, even after the very first lifetime episode.

Investigators have generated kidney-like organoids - complete with nephrons, collecting ducts, stroma, and vasculature - from induced pluripotent stem cells.

In an effort to expand the range of ways graduate programs prepare students to be scholars and practitioners in technical and professional communication, this article argues for a fresh direct reengagement with stories, storytelling, and narrative as valuable ways of studying and effectively producing the varied texts of the workplace. The previous call for acknowledging the value of narrative traces back almost 30 years, and story is still being used in a variety of compelling ways, even as an overt regard for narrative has not been sustained. What may be lacking is a systematic way to transf...

After a decade of economic crisis and ongoing technological innovation, scholars and journalists have argued that new production patterns for news media are required befitting the emergence of entrepreneurial journalism. This study investigated the effects of prior experience with social problems, empathy, moral obligation, social entrepreneurial self-efficacy, and perceived social support on the social entrepreneurial intentions of 421 Taiwanese journalists. A regression analysis suggests a prominent association of social support with social entrepreneurial intentions, followed by social entr...

Abstract What has the rise of Amazon meant for the novel? This essay argues that in shifting the scene of innovation from the novel’s form to the ways and means of its distribution, the company has redefined authorship as the entrepreneurial provision of good service to readers and reading itself as a repeatable experience of erotic self-care. Conceived in this way, all fiction is “genre fiction,” including so-called literary fiction, which for Amazon is simply one modality of the perverse pursuit of customer satisfaction among others. As an occasion for felicitous repetition, genre fiction ta...

Pentylenetetrazole (PTZ) is widely used in antiepileptic drug discovery studies, and PTZ kindling model is very important to understand the pathophysiology of epilepsy.

In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance.

Embelin (EMB) treatment increased the seizure threshold to hind limb extension (HLE) in the ICES test and decreased the seizure scores in the kindling experiment, and was also observed to be protecting the kindled animals from cognition and depression-like behavior.

An optogenetic variant of the classical kindling model of epilepsy in which activatable cells are both genetically defined and fluorescently tagged is developed, with the added benefit that the role of specific neuronal populations in epileptogenesis can be studied.

With optokindling, neuroscientists can elucidate the circuit changes that underpin epilepsy while minimizing the contribution of confounding factors such as brain damage and inflammation.

With this method, vulnerability to PTZ-mediated seizures or the degree of aggravation of epileptic seizures was estimated and the use of this method for screening anti-epileptic drugs and epilepsy-related genes was used.

Epileptogenesis in AIE is likely to arise from the synergistic effect of both innately driven neuroinflammation and antibody‐induced hyperexcitability, which produce persistent drug‐resistant seizures that contribute to the morbidity seen in AIe.

The hypothesis of a relationship between certain neurophysiological mechanisms and specific clinical phenomena where jouissance is “kindled” and outside the control of the symbolic process is put forth, and certain phenomena of automatism and certain deficits could be seen as psychosomatic disorders of the brain.

Assessment of the antiepileptogenesis effects of LFS with the same protocol applied either just before or immediately after kindling stimulations found LFS-K showed more inhibiting effect than K-LFS, but the difference was not statistically significant.

CysLT1 antagonists appear to emerge as a promising adjunctive treatment for refractory seizures, and additional studies are necessary to evaluate the clinical implications of this research.

PTZkindling model may improve understanding of the seizures development provided that the differences existing between the phases of kindling model are taken into account.

The data suggest TSP1 in particular may control CACNA2D2 levels and could be a modifier of seizure susceptibility, and are more susceptible to seizures.

CBD and THC both have antiseizure properties in the amygdala-kindling model, although THC produces suppression of the amygdala focus only at doses that produce hypolocomotion, and the addition of small amounts of THC greatly improves the effectiveness of CBD.

The results confirm that selection and breeding on the basis of responses to repeated pathway activation by stimulation can produce enduring modification of genetic background influencing behavior and suggest that genetic background underlying susceptibility or resistance to seizure-induced plasticity in hippocampal circuitry also differentially influences distinct behaviors and learning that depend on circuitry activated by the kindling selection process.

It is thought that people who fall ill with serious psychotic disorder pay selective attention to a constant stream of many different auditory and quasi-auditory events because of different "cultural invitations"-variations in ways of thinking about minds, persons, spirits and so forth.

Images captured under low-light conditions often suffer from (partially) poor visibility. Besides unsatisfactory lightings, multiple types of degradations, such as noise and color distortion due to the limited quality of cameras, hide in the dark. In other words, solely turning up the brightness of dark regions will inevitably amplify hidden artifacts. This work builds a simple yet effective network for \textbf{Kin}dling the \textbf{D}arkness (denoted as KinD), which, inspired by Retinex theory, decomposes images into two components. One component (illumination) is responsible for light adjust...

Unlike the animal models of PTE in which recurrent seizures occur spontaneously after TBI, in this study, epilepsy is elicited by kindling stimulations.

Amazon leads the market in ebooks with the Kindle brand, which encompasses a range of dedicated e-reader devices and a large ebook store. Kindle users are able to share the experience of reading ebooks purchased from Amazon by selecting passages of text for upload to the Kindle Popular Highlights website. In this article, I propose that the Kindle Popular Highlights database contains evidence that readers are re-appropriating commonplacing – the act of selecting important passages from a text and recording them in a separate location for later re-use – while reading public domain titles on the...

The results are suggestive of the antiepileptogenic potential of borneol in the PTZ-induced kindling model of epilepsy, and thus, it could be a prospective molecule in the treatment of epilepsy.

Interestingly, DIC rather than MEL enhanced the anticonvulsant effect VAL and mitigated inflammation and oxidative stress in PTZ-kindled mice.

The evaluation outcome shows that the participants had a good and rich mobile experience with the Amazon Kindle e-book mobile app.

"How do gods and spirits come to feel vividly real to people-as if they were standing right next to them? Humans tend to see supernatural agents everywhere, as the cognitive science of religion has shown. But it isn't easy to maintain a sense that there are invisible spirits who care about you. In How God Becomes Real, acclaimed anthropologist and scholar of religion T. M. Luhrmann argues that people must work incredibly hard to make gods real and that this effort-by changing the people who do it and giving them the benefits they seek from invisible others-helps to explain the enduring power o...

The results showed that ARK was able to impair breathing function, demonstrating a strong coupling between amygdala and the respiratory neurons in the brainstem, with potential impact in respiratory failures, frequently fatal, during or after epileptic seizures in chronic animal models and in patients.

The article assesses the implications of digitization on the personal experience of consuming books, where issues relating to ownership, intimacy and privacy are especially relevant.

Results indicate that early childhood adversity sensitized bipolar participants to the effects of recent stressors only for depressive episodes and not hypomanic episodes within BD, which was particularly the case with minor negative events.

The chronically-infected rats achieved focal and also generalized seizures earlier than the rats with acute infection and Toxoplasmosis might be considered as a risk factor for acquisition of epilepsy.

Experimental evidence is provided that a combination therapy of lycopene along with sodium valproate attenuated seizure and oxidative stress against pentylenetetrazol-induced kindling in mice.

Interpretable research on flavonoid will support the clinical evidence for the recommendation of flavonoids as supplements with antiepileptic drugs (AEDs) for curtailing pharmacoresistant epilepsy and AED-associated comorbidities.

It is demonstrated that ketogenic diet can indeed improve impaired spatial reference memory in PTZ-kindled rats, and KD can improve the expression of NR2B and GluR1.

It is concluded that there is an activation of the intrinsic and extrinsic apoptotic pathways in the cerebellum of rats exposed to the kindling model.

The aims of this study were to examine whether lamotrigine could prevent the development of seizure in pentylenetetrazole kindling rats.

It is concluded that P. austroarabica extract ameliorated seizure activity and protected cortical and hippocampal neurons against pentylenetetrazole-induced kindling in mice.

Cardiac morphological alterations in a pentylenetetrazol-kindled rat model provided evidence that changes in cardiac morphology may be related to autonomic CV dysfunctions occurring during SUDEP while also opening up more avenues to better develop novel drugs for the treatment of this disorder.

Agomelatine alleviated PTZ-kindling-associated behavioral despair and favorably modulated liver enzymes and could be explored as an adjunct to antiepileptic drugs for seizure control and for alleviating epilepsy-associated depression.