Top Research Papers on PCOS

This third edition covers the aetiology, pathology, impact on fertility and effective medical and surgical management of PCOS, and a new chapter on the patient's perspective has been included, bringing valuable insight into the lived experience of the condition.

The needs and priorities of those with PCOS are discussed, including lifestyle, and medical and infertility treatment, and the status of international evidence-based guidelines and translation are discussed to support patient self management, healthcare provision, and to set research priorities.

Despite affecting ~11-13% of women globally, polycystic ovary syndrome (PCOS) is a substantially understudied condition. PCOS, possibly extending to men's health, imposes a considerable health and economic burden worldwide. Diagnosis in adults follows the International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome, requiring two out of three criteria - clinical or biochemical hyperandrogenism, ovulatory dysfunction, and/or specific ovarian morphological characteristics or elevated anti-Müllerian hormone. However, diagnosing adolescents omits ovarian mo...

The rationale for and the limitations of these criteria are reviewed, as well as which criteria to use and when, and the promise of objective data mining approaches for biologically relevant disease classification are discussed.

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The immune regulation involved in the pathogenesis of PCOS is summarized to pave the way for the development of better PCOS treatment options in the near future.

The data suggests that the body mass index was not correlated with increased LH/FSH ratio, which was the same in normal BMI women, and healthcare professionals need to think about ways to normalize this ratio beyond weight reduction.

The associations between MPO activity and the MPO G‐463A and CYBA C242T polymorphisms in Chinese women with PCOS are investigated.

The complexity of the disorder, and the impact on quality of life, requires a timely diagnosis, screening for complications, and management strategies for the long-term health issues associated with polycystic ovary syndrome.

The main objective is to provide a background of autophagy in the ovary, its possible connection with PCOS and suggested a novel proposal for future studies to aid a better understanding of PCOS pathogenesis.

This paper focuses on the data-driven diagnosis of polycystic ovary syndrome (PCOS) in women and finds that RFLR is suitable for reliably classifying PCOS patients.

The findings suggest that diet is an effective, acceptable and safe intervention for relieving IR, and professional dietary advice should be offered to all PCOS patients.

This review intends to emphasise the key role of oxidative stress and chronic inflammation in PCOS pathogenesis; however, the exact molecular mechanism is mostly unknown and requires further investigation.

A narrative review was conducted to provide an update and summarize the available evidence on the management of polycystic ovary syndrome related infertility and suggest alternative and adjunctive treatments, like inositol, vitamin D, bariatric surgery and acupuncture.

Polycystic ovary syndrome (PCOS) affects 1 in 5 women of reproductive age, and is characterized by menstrual irregularities, clinical or biochemical hyperandrogenism, and the presence of polycystic ovary morphology. One of the recommended treatment strategies in the international evidence-based guidelines is lifestyle modification, which includes diet and exercise, with the aim of improving a range of health outcomes. The incurable nature of PCOS reinforces the importance of developing novel and innovative symptomatic relief strategies, which are currently the only available approaches for imp...

Attention should be directed to maintain a high standard of care for complex patients such as many women with PCOS and provide relevant practical recommendations for optimal management in the setting of this fast moving pandemic.

How AGE formation, inflammation, and oxidative stress are significantly essential in PCOS progression is summarized, and a collection of specific genes phenotypically linked with PCOS is outlined.

The interplay between inflammatory cytokines in the PCOS ovary strongly implies that inflammation is one of the most potent risk factors of PCOS, which should be considered for new treatment or management of the disease and to improve women's health.

The results suggest that a KD may be considered as a valuable non pharmacological treatment for PCOS and longer treatment periods should be tested to verify the effect of a KD on the dermatological aspects of PCOS.

Polycystic ovary syndrome (PCOS) is the most common reproductive and metabolic disorder affecting women of reproductive age. PCOS has a strong heritable component, but its pathogenesis has been unclear. Here, we performed RNA sequencing and genome-wide DNA methylation profiling of ovarian tissue from control and third-generation PCOS-like mice. We found that DNA hypomethylation regulates key genes associated with PCOS and that several of the differentially methylated genes are also altered in blood samples from women with PCOS compared with healthy controls. Based on this insight, we treated t...