Top Research Papers on Weight Loss

There is no single best strategy for weight management, and strategies for weight loss and its maintenance should be individualized, and healthcare providers must choose the best strategy based on patient preferences.

The evidence supports the recommendations for intakes of protein above the current guidelines of 0.8 g/kg body weight/d for the healthy elderly population to also be incorporated into the dietary prescription for weight management in this age group.

This Viewpoint explores the effects of weight loss achieved through GLP-1–based antiobesity medications on weight regain, fat-free mass, and skeletal muscle mass in people with obesity.

Key common influential characteristics of success were identified, which can inform future prospective studies and weight management initiatives, and the first systematic review of information about successful weight loss maintenance obtained from weight control registries is reviewed.

Insight is sought on unanswered questions over how weight loss is achieved following bariatric surgery which may eventually lead to safer, nonsurgical weight-loss interventions or combinations of medications with surgery.

Obesity is best managed by a multidisciplinary clinical team that integrates diet, exercise, and pharmacotherapy and bariatric surgery is needed to manage T2D and obesity in select patients.

Research into factors potentially contributing to inter-individual variability in response to treatments for obesity, with a focus on studies in humans is reviewed, to guide more personalized approaches to the treatment of obesity.

The reported impact of weight loss by diet, exercise, or bariatric surgery on circulating and tissue-specific glucocorticoid levels is summarized and the therapeutic possibility of reversing glucoc Corticoid-associated metabolic disorders is examined.

A high-intensity, lifestyle-based treatment program for obesity delivered in an underserved primary care population resulted in clinically significant weight loss at 24 months.

Clinicians should recommend an adapted lifestyle, and when necessary, a drug combination tailored to individual needs and comorbidities, as an update on promising diets and pharmacological aids is presented.

Although most adults with overweight or obesity experienced 5% or greater weight loss with treatment, the benefit was greater with tirzepatide.

Data indicate that therapeutic targeting of the GDF15–GFRAL pathway may be useful for maintaining energy expenditure in skeletal muscle during caloric restriction, and this effect of GDF15 to maintain energy expenditure during calorie restriction requires a GFRAL–β-adrenergic-dependent signalling axis that increases fatty acid oxidation and calcium futile cycling in the skeletal muscle of mice.

The Mediterranean diet is a plant-based,high-fat, high-unsaturated fat dietary pattern that has been consistently associated with lower rates on non-communicable diseases and total mortality in prospective studies and with reduced CVD in the PREDIMED trial.

Among patients with obesity, a regimen of time-restricted eating was not more beneficial with regard to reduction in body weight, body fat, or metabolic risk factors than daily calorie restriction.

Patients with COVID‐19 disease are prone to develop significant weight loss and clinical cachexia, and there is a high medical need to prevent long‐term disability due to acute COVID­19 disease.

This review presents the current knowledge about diseases associated with childhood obesity and how they are affected by weight loss, and indicates that early weight loss—that is, before puberty—is more beneficial, but there are marked disease‐specific differences.

A strategy combining exercise and liraglutide therapy improved healthy weight loss maintenance more than either treatment alone and was associated with improvements in the glycated hemoglobin level, insulin sensitivity, and cardiorespiratory fitness.

A generalization for these methods that manifests as a scaling parameter which balances the relative importance of the different constraints imposed by partial differential equations is introduced, which derives a choice for the scaling parameter that is optimal with respect to a measure of relative error.

This randomized trial compared time-restricted eating with eating over a period of 12 or more hours while matching weight-loss counseling across groups to determine whether practicing TRE by eating early in the day is more effective for weight loss, fat loss, and cardiometabolic health.

Semaglutide treatment in a regular clinical setting was associated with weight loss similar to that seen in randomized clinical trials, which suggests its applicability for treating patients with overweight or obesity.