Intrinsic Mechanisms of Pain Inhibition: Activation by Stress
SciencePublished 14 December 1984
Gregory W. Terman, Yehuda Shavit, James W. Lewis, J. Timothy Cannon, John C. Liebeskind
Citations529
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
This dissection of stress analgesia has begun to integrate divergent findings concerning pain inhibition and also to account for some of the variance that has obscured the reliable measurement of the effects of stress on tumor growth and immune function.
Abstract
Portions of the brain stem seem normally to inhibit pain. In man and laboratory animals these brain areas and pathways from them to spinal sensory circuits can be activated by focal stimulation. Endogenous opioids appear to be implicated although separate nonopioid mechanisms are also evident. Stress seems to be a natural stimulus triggering pain suppression. Properties of electric footshock have been shown to determine the opioid or nonopioid basis of stress-induced analgesia. Two different opioid systems can be activated by different footshock paradigms. This dissection of stress analgesia has begun to integrate divergent findings concerning pain inhibition and also to account for some of the variance that has obscured the reliable measurement of the effects of stress on tumor growth and immune function.
Keywords
MedicineNeuroscience
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PeptidesApparent involvement of opioid peptides in stress-induced enhancement of tumor growth
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54 Citations1983G.W. Terman, J.W. Lewis +1 more
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49 Citations1983James W. Lewis, J. Timothy Cannon +1 more
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41 Citations1984L.R. Watkins, Robert C. Drugan +5 more
An initial attempt at defining the neural circuitry involved in these phenomena is sought by examining the effect of bilateral dorsolateral funiculus (DLF) lesions and decerebration, which revealed that pathways within the spinal cord DLF are critical for the production of short-term non-opiate analgesia, short- term opiate analgesIA, and long-term opiates analgesia since bilateral DLF lesions abolished all three pain inhibitory effects.
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40 Citations1981R.G. Hill, Susan J. Ayliffe
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39 Citations1978Carl D. Richards
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39 Citations1983J. Timothy Cannon, James W. Lewis +2 more
The analyses indicate that in the same animals, complete and partial NRM lesions disrupt morphine analgesia; however, this effect is not mediated by the same substrate involved in either form of stress analgesia.
Physiology & BehaviorOpiate antagonists overcome the learned helplessness effect but impair competent escape performance
34 Citations1983Wayne G. Whitehouse, J. Walker +2 more
A significant role is suggested for endogenous opiates in the induction of learned helplessness as well as in the acquisition of efficient escape behavior in rats pretrained with escapable shocks.
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33 Citations1982Kenneth D. Carr, Edgar E. Coons
Hypothalamic stimulation in rats both reduces escape from noxious hind brain stimulation and sustains self-administration only when hindbrain stimulation is inescapable.
Physiology & BehaviorNaloxone partially antagonizes post-encounter analgesia and enhances defensive responding in male rats exposed to attack from lactating conspecifics
32 Citations1983R.J. Rodgers, C.A. Hendrie +1 more
Results suggest that exposure to attack from lactating conspecifics activates both opioid and nonopioid analgesia mechanisms in male intruders, and the possible importance of psychological factors in the activation of endogenous pain inhibitory mechanisms in rats is discussed.
Brain ResearchBody region shocked need not critically define the neurochemical basis of stress analgesia
21 Citations1984J. Timothy Cannon, Gregory W. Terman +2 more
It is reported that either opioid or non-opioid stress analgesia can be evoked from either front or hind paws depending only on footshock intensity when duration and temporal pattern are held constant.
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17 Citations1983A. John MacLennan, Robert C. Drugan +1 more
An ‘opioid’ form of analgesia (‘long-term analgesia’) was completely blocked by scopolamine, which suggests that muscarinic cholinergic processes may play an important role in this analgesia and in other types of endogenous pain control.
Behavioral NeuroscienceVentromedial septal lesions in rats reduce the effects of inescapable shock on escape performance and analgesia.
17 Citations1983John E. Kelsey, Margaret D. Baker
It is hypothesized that ventromedial septal lesions reduce these effects of exposure to inescapable shock either by reducing the ability of the rats to learn that their responses and shocks were uncorrelated or by reduced the emotional impact of this lack of correlation.
Experimental NeurologyEffects of morphine on spontaneous multiple-unit activity: Possible relation to mechanisms of analgesia and reward
16 Citations1979Gideon Urca, Richard L. Nahin +1 more
The data lend further support to the suggestion that morphine exerts its analgesic action by activating an endogenous analgesic system and that the periaqueductal gray constitutes an important part of such a system.
Journal of Neural TransmissionThe role of consciousness in stress-induced analgesia
14 Citations1981Troels S. Jensen, Donald F. Smith
The findings suggest that conscious processes are necessary for the occurrence of SIA, and an elevation in pain threshold indicative of stress-induced analgesia (SIA) appeared in rats shocked while awake, but not in those shocked while anaesthetized.
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13 Citations2008Alan T. Lim, Tian P. S. Oei +1 more
In rats, the analgesic response induced by prolonged intermittent foot-shock is abolished by naloxone or adrenalectomy, and is restored in adrenalectomized animals by the administration of dexamethasone or corticosterone, but not deoxycorticosterone.
PainBehavioral evidence for an opiate pituitary mechanism subserving conditioned analgesia
10 Citations1983M. Gaiardi, M. Bartoletti +3 more
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International Journal of NeuroscienceDissociation of Analgesic and Hyperphagic Responses Following 2-Deoxy-D-Glucose
10 Citations1983Richard J. Bodnar, Elisse Kramer +3 more
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