Neurochemistry and Child Psychiatry
Journal of the American Academy of Child PsychiatryPublished 1 June 1977
Donald J. Cohen, J. Gerald Young
Citations62
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TL;DR
Studies of neurotransmitter metabolism in conjunction with other types of research strategies offer promise for clarifying the basis for some serious developmental disturbances of childhood and the impact of psychoactive medication.
Abstract
Normal brain function depends on the integration of the synthesis, storage, release, and inactivation of neurotransmitters localized in different brain structures and pathways. Neurotransmitters, such as dopamine, serotonin, and acetylcholine, are implicated in various neurological and psychiatric diseases and in a broad range of normal physiological processes. Neurotransmitters, metabolites, and enzymes can be measured in cerebrospinal fluid, blood, and urine, permitting clinical researchers to study correlations between metabolic and behavioral dimensions. There are serious methodological problems which must be considered in interpreting biological research in child psychiatry. However, studies of neurotransmitter metabolism in conjunction with other types of research strategies offer promise for clarifying the basis for some serious developmental disturbances of childhood and the impact of psychoactive medication.
Keywords
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Archives of General PsychiatryBiogenic Amines in Autistic and Atypical Children
133 Citations1974Donald J. Cohen
The concentrations of HVA and 5HIAA in the CSF are thought to reflect the rate of formation in the brain of their parent amines, dopamine and serotonin, respectively, and are significantly correlated with each other.
Archives of General PsychiatryDopamine and Serotonin Metabolism in Neuropsychiatrically Disturbed Children
133 Citations1977Donald J. Cohen
There were no significant differences in metabolite concentrations among autistic, nonautistic psychotic, aphasic, and cognitively and attentionally impaired groups, or between the developmentally disabled and contrast groups of children.
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