Psychobiological Mechanisms of Resilience and Vulnerability: Implications for Successful Adaptation to Extreme Stress
American Journal of PsychiatryPublished 30 January 2004
Dennis S. Charney
Citations1,599
SJR quartileQ1
SJR score5.27
SNIP3.68
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Abstract
The opportunity now exists to bring to bear the full power of advances in our understanding of the neurobiological basis of behavior to facilitate the discoveries needed to predict, prevent, and treat stress-related psychopathology.
Keywords
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295 Citations2002Tracy L. Bale, Roberto Picetti +4 more
Results indicate that both CRFR1 and CRFR2 have critical roles in gene regulation and the maintenance of homeostasis in response to stress.
NeuropsychopharmacologyEvaluation of Antidepressant-related Behavioral Responses in Mice Lacking the Serotonin Transporter
287 Citations2002Andrew Holmes
5-HTT knockout mice provide a valuable tool for delineating the neuropsychopharmacological actions of antidepressants, and the anti-immobility effects of the serotonin reuptake inhibitor, fluoxetine, were abolished in 5-HTt −/− mice, confirming that the 5- HTT gene is required for the behavioral effects of fluoxettine.
Trends in Endocrinology and MetabolismFunctional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists
276 Citations2002Dimitris Grammatopoulos, George P. Chrousos
Because of the complex network of multiple CRH receptor subtypes and their tissue- and agonist-specific signaling diversity, antagonists need to be developed that can target specificCRH receptor isoform-driven signaling pathways.
Journal of NeuroscienceThe Amygdala Modulates Memory Consolidation of Fear-Motivated Inhibitory Avoidance Learning But Not Classical Fear Conditioning
267 Citations2000Ann E. Wilensky, Glenn E. Schafe +1 more
The GABAA agonist muscimol is used to functionally inactivate the lateral and basal nuclei of the amygdala immediately after single-trial Pavlovian fear conditioning or single- trial inhibitory avoidance learning, indicating that the amygdala plays an essential role in the acquisition of Pavlovians fear conditioning and contributes to the modulation of memory consolidation of inhibitoryavoid.
American Journal of Medical GeneticsEndophenotypes in bipolar disorder†
264 Citations2002Robert H. Lenox, Todd D. Gould +1 more
Findings in patients with bipolar disorder that may eventually be useful as endophenotypes include abnormal regulation of circadian rhythms, response to sleep deprivation, P300 event-related potentials, behavioral responses to psychostimulants and other medications, Response to cholinergics, increase in white matter hyperintensities, and biochemical observations in peripheral mononuclear cells.
PsychoneuroendocrinologyEffects of competition and its outcome on serum testosterone, cortisol and prolactin
261 Citations1999Ferrán Suay, Alicia Salvador +6 more
The relationships found between T changes in competition and motivation to win, as well as between C response and self-efficacy suggest that in humans hormonal response to competition is not a direct consequence of winning and losing but rather is mediated by complex psychological processes.
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