Top Research Papers on Immunology

Current knowledge of aberrant immune responses during sepsis and recent initiatives to stratify patients with sepsi into subgroups that are more alike from a clinical and/or pathobiological perspective are reviewed, which could be key for identification of patients who are more likely to benefit from specific immune interventions.

The Manual of Immunological Methods represents the collaboration of the Canadian Network of Toxicology Centers, a non-profit network of university-based scientists dedicated to research, training, risk assessment, and communication. This manual provides detailed immunological methods that can be utilized by researchers or practitioners who want to

Veterinary clinical immunology , Veterinary clinical immunology , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی

The next frontier in RA is the development of curative interventions, for example, reprogramming T cell defects during the period of asymptomatic autoimmunity, discusses how the progressive loss of immune cell tolerance underlies the immunopathology associated with rheumatoid arthritis.

The underlying immunological basis of various asthma endotypes is reviewed by discussing results obtained from animal studies as well as results generated in clinical studies targeting specific immune pathways.

The current picture is one of convergence towards a map of an immunopathogenic aetiology of long COVID, though as yet with insufficient data for a mechanistic synthesis or to fully inform therapeutic pathways.

Findings related to key immunological aspects of cholangiocarcinoma are discussed, including the heterogeneous landscape of immune cells within the tumour microenvironment, the immunomodulatory effect of the microbiota and IDH1 mutations, and the association of immune-related signatures and patient outcomes.

It is highlighted that teasing out the precise roles of different immune cell subsets at different stages of the disease will be key to effective treatment strategies and may identify novel therapeutic targets that replace the need for cell ablation.

The key role of the immune system in mediating fibrosis regression is discussed and avenues for future study to elucidate potential approaches to targeting inflammatory cells in fibrotic disorders are highlighted.

The Handbook of Cancer and Immunology presents the most updated biomedical and clinically relevant reviews in cancer immunology and immunotherapy.

(Cell 184, 1469–1485; March 18, 2021)Figure 5Central role of Th2 and innate lymphocytes in controlling key features of type 2-high asthma (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) (Cell 184, 1469–1485; March 18, 2021) The basic immunology of asthmaHammad et al.CellMarch 11, 2021In BriefHammad and Lambrecht review the immunological basis of asthma endotypes by discussing results from animal studies that have unraveled molecular pathways and clinical studies targeting specific immune pathways using molecule-specific biologics. Full-Text PDF Open Archive

It is proposed that studying the immune system in humans, who are genetically diverse and afflicted by a multitude of diseases, offers both a direct link to medicine and the very real prospect of discovering fundamentally new human biology.

It is indicated that immune cells express genes differentially in response to stress, suggesting individual variabilities in the immune response against stress, which underscores the need for a personalized approach to stress management.

In a Perspective, Andrea Graham argues that using a more naturalized biotic and abiotic setting can help capture a more accurate picture of the immune system.

Different roles of T cells, B cells, and cytokines for the immunopathology and disease course of psoriasis are described.

It is hoped that the knowledge gained from this COVID-19 research will be applied in studies of inflammatory processes involved in critical and chronic illnesses, which remain a major unmet need.

Abstract Nanomaterials (NMs) have revolutionized multiple aspects of medicine by enabling novel sensing, diagnostic, and therapeutic approaches. Advancements in processing and fabrication have also allowed significant expansion in the applications of the major classes of NMs based on polymer, metal/metal oxide, carbon, liposome, or multi-scale macro-nano bulk materials. Concomitantly, concerns regarding the nanotoxicity and overall biocompatibility of NMs have been raised. These involve putative negative effects on both patients and those subjected to occupational exposure during manufacturing...

After genetic modifications are established, the pig is the best animal model for future xenotransplantation to reduce the problem of organ shortage for organ transplantation.

This review covers three aspects of dendritic cell (DC) biology connected with antitumor immune responses but are not specifically oriented toward therapeutic use, and reviews recent advances in the development of the cDC1 subset of DCs.

A viewpoint on recent advances of 3D in vitro tumor immunotherapy models is presented, and translational applications of tumor organoids for immuno-oncology research, immunotherapy modeling, and precision medicine are proposed.