18-Month mortality and perinatal exposure to zidovudine in West Africa
AIDSPublished 1 April 2001
François Dabis, Narcisse Elenga, Nicolas Méda, Valériane Leroy, Ida Viho, Olivier Manigart
Citations77
SJR quartileQ1
SJR score1.21
SNIP0.90
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Peripartum maternal zidovudine exerts a protective effect for at least 8 months and is safe and beneficial to African children born to HIV-1-infected mothers.
Abstract
Mother-to-child transmission reduction by zidovudine is safe and beneficial to African children. The mortality of HIV-1-infected children is high. Peripartum maternal zidovudine exerts a protective effect for at least 8 months.
Keywords
Immunology and MicrobiologyMedicine
The LancetIntrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial
1,646 Citations1999Laura Guay, Philippa Musoke +17 more
Nevirapine lowered the risk of HIV-1 transmission during the first 14-16 weeks of life by nearly 50% in a breastfeeding population, suggesting this simple and inexpensive regimen could decrease mother-to-child HIV- 1 transmission in less-developed countries.
JAMAEffect of Breastfeeding and Formula Feeding on Transmission of HIV-1
924 Citations2000Ruth Nduati, Grace C. John +9 more
AIDSAdverse effects of reverse transcriptase inhibitors
849 Citations1998Kees Brinkman, Hadewych J. M. ter Hofstede +3 more
Although the introduction of protease inhibitors has changed management of HIV infection drastically, this cerebro-protective property will assert the role of these nucleo-side RT inhibitors (NRTI) as a cornerstone ofantiretroviral therapy.
The LancetShort-course zidovudine for perinatal HIV-1 transmission in Bangkok, Thailand: a randomised controlled trial
799 Citations1999Nathan Shaffer, Rutt Chuachoowong +11 more
A short course of twice-daily oral zidovudine was safe and well tolerated and, in the absence of breastfeeding, can lessen the risk for mother-to-child HIV-1 transmission by half.
The LancetPersistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues
665 Citations1999Stéphane Blanche, Marc Tardieu +12 more
The hypothesis of a link between mitochondrial dysfunction and the perinatal administration of prophylactic nucleoside analogues supported, current recommendations for zidovudine monotherapy should however be maintained.
The LancetShort-course oral zidovudine for prevention of mother-to-child transmission of HIV-1 in Abidjan, Côte d'Ivoire: a randomised trial
550 Citations1999Stefan Z. Wiktor, Ehounou Ekpini +9 more
Short-course oral zidovudine was safe, well tolerated, and decreased mother-to-child transmission of HIV-1 at age 3 months, and substantial efforts will be needed to ensure successful widespread implementation of such a regimen.
The Lancet6-month efficacy, tolerance, and acceptability of a short regimen of oral zidovudine to reduce vertical transmission of HIV in breastfed children in Côte d'Ivoire and Burkina Faso: a double-blind placebo-controlled multicentre trial
508 Citations1999François Dabis, Philippe Msellati +16 more
A short course of oral zidovudine given during the peripartum period is well accepted and well tolerated, and provides a 38% reduction in early vertical transmission of HIV-1 infection despite breastfeeding.
JAMALack of Long-term Effects of In Utero Exposure to Zidovudine Among Uninfected Children Born to HIV-Infected Women
343 Citations1999Mary Culnane
There were no significant differences between children exposed to zidovudine and those who received placebo in terms of sequential data on lymphocyte subsets; weight, height, and head circumference z scores; and cognitive/developmental function.
The LancetIntegrated approach to child health in developing countries
236 Citations1999Jim Tulloch
Through improving the coordination and quality of services provided by existing child health and other programs the IMCI strategy will help increase the effectiveness of care and in time reduce recurrent costs.
The LancetAdvances and research directions in the prevention of mother-to-child HIV-1 transmission
216 Citations2000Lynne Mofenson, James McIntyre
The challenge for the next decade is to simultaneously address questions relevant to both epidemics while bridging the gap in prevention of perinatal transmission between more-developed and less-developed countries.
Williams & Wilkins eBooksPediatric AIDS : the challenge of HIV infection in infants, children, and adolescents
210 Citations1998Philip A. Pizzo, Catherine M. Wilfert
New England Journal of MedicineRelation of the Course of HIV Infection in Children to the Severity of the Disease in Their Mothers at Delivery
200 Citations1994Stéphane Blanche, Marie-Jeanne Mayaux +11 more
AIDSSafety of the maternal–infant zidovudine regimen utilized in the Pediatric AIDS Clinical Trial Group 076 Study
164 Citations1998Rhoda Sperling, David E. Shapiro +12 more
There were no identified problems that would alter current recommendations for the routine use of ZDV for the prevention of mother–child HIV-1 transmission and there was no serious pattern of adverse pregnancy outcomes associated withZDV use.
JAMANeonatal Characteristics in Rapidly Progressive Perinatally Acquired HIV-1 Disease
162 Citations1996M. J. Mayaux
These prognostic markers, particularly virological parameters, are of value in monitoring children infected by HIV and might serve as a basis for early therapeutic intervention in children born to infected mothers.
AIDSEstimating the rate of mother-to-child transmission of HIV. Report of a workshop on methodological issues Ghent (Belgium), 17–20 February 1992
130 Citations1993François Dabis, Philippe Msellati +5 more
A common methodology was developed and can now be applied to all studies with sufficient follow-up and comparisons made between transmission rates, essential for assessing determinants of transmission and for the development of a common approach for the evaluation of interventions aimed at reducing or interrupting MTCT of HIV.
Journal of Acquired Immune Deficiency Syndromes & Human RetrovirologyLack of Tumors in Infants With Perinatal HIV-1 Exposure and Fetal/Neonatal Exposure to Zidovudine
122 Citations1999I. Celine Hanson, Tracy A. Antonelli +10 more
Evaluated the short-term risk for tumors in 727 children with known ZDV exposure enrolled into the PACTG 076/219 and the Women and Infants Transmission Study (WITS), finding no tumors of any nature were observed.
The LancetHIV nucleoside analogues: new adverse effects on mitochondria?
66 Citations1999Andrew AM Mor ris, Andrew Carr
The Pediatric Infectious Disease JournalREPORT OF A WORKSHOP FOR CLINICAL RESEARCH
65 Citations1998Philippe Lepage, Rosemary Dray‐Spira +7 more
Clinical research priorities included primary prophylaxis of opportunistic and bacterial infections; case management of persistent diarrhea; reassessment of the performance of p24 antigen for diagnostic and prognosis use; studies on the etiology of pulmonary infections; long term observational pediatric cohorts.
AIDSRapid disease progression in HIV-1 perinatally infected children born to mothers receiving zidovudine monotherapy during pregnancy
64 Citations1999The Italian Register for HIV Infection in Children
Comparison of HIV-1-infected children whose mothers were treated with ZDV with children whosemothers were not treated showed that the former group had a higher probability of developing severe disease and a lower survival than the latter.
AIDSPreventing mother-to-child transmission of HIV-1 in Africa in the year 2000
61 Citations2000François Dabis, Valériane Leroy +4 more
A critical review of 18 randomized trials and other relevant studies from developing and industrialized countries shows that a short regimen of peripartum ARV with alternatives to breastfeeding such as early weaning or breast milk substitutes from birth currently represent the best option to reduce MTCT of HIV in Africa.
The Lancet15-month efficacy of maternal oral zidovudine to decrease vertical transmission of HIV-1 in breastfed African children
49 Citations1999François Dabis, L. Dequae-Merchadou +3 more
In a randomised, double-blind comparison of a maternal short regimen of oral zidovudine with placebo in West Africa the 15-month efficacy of zidvudine in preventing mother-to-child transmission of HIV-1 infection was estimated at 30% (95% CI -2 to 52).
BMJRetrospective study of maternal HIV-1 and HIV-2 infections and child survival in Abidjan, Cote d'Ivoire
44 Citations1994Kevin M. De Cock, F. Zadi +9 more
Maternal HIV-2 infection has less influence on child survival than infection with HIV-1, probably because of a lower vertical transmission rate.
The Journal of Infectious DiseasesDisease Progression and Early Viral Dynamics in Human Immunodeficiency Virus–Infected Children Exposed to Zidovudine during Prenatal and Perinatal Periods
32 Citations2000Louise Kuhn, Elaine J. Abrams +8 more
Zdv exposure was associated with 1.8-fold (95% confidence interval, 1.02-3.11) increased risk of progressing to AIDS or death after adjusting for year of birth, maternal CD4 cell count, maternal AIDS diagnosis, and subsequent antiretroviral therapy of the child.
The Journal of PediatricsThe effects of zidovudine in the subset of infants infected with human immunodeficiency virus type-1 (Pediatric AIDS Clinical Trials Group Protocol 076)
31 Citations1999George McSherry, David E. Shapiro +6 more
Zidovudine therapy during pregnancy and labor and in the neonatal period for 6 weeks failed to have a major effect on rapid progression of disease, timing of transmission, and viral replication in HIV-infected infants, and resistance to zidovUDine did not develop during study treatment.
AIDSMortality impact of AIDS in Abidjan, 1986–1992
27 Citations1996Michel L. Garenne, Maria Madison +4 more
There was a marked increase in death rates starting in 1986, date of the first diagnosed AIDS cases in the city, and most of it was considered to be attributable to AIDS and related infections, tuberculosis in particular.
AIDSPrevention of infectious complications of paediatric HIV infection in Africa
20 Citations2000Rosemary Dray‐Spira, Philippe Lepage +1 more
A critical appraisal of the possible approaches to consider in the IMCI strategy for the prevention of post-neonatal infectious complications of pediatric HIV infection is presented and recommendations from the Ghent International Working Group on HIV in Women and Children shall be dealing with immunization strategies vitamin A supplementation nutritional management and drug prophylaxis.
The Journal of PediatricsShortened survival in infants vertically infected with human immunodeficiency virus with elevated p24 antigenemia
18 Citations1995Nina Arlievsky, Henry Pollack +4 more
Elevated p24 antigenemia in the first 6 months of life is associated with shorter survival and may be a useful predictor of outcome.
NatureHIV infection in Africa
8 Citations1992H.A. Wilkins
Aids in Africa: Its Present and Future Impact by Tony Barnett Piers Blaikie and JBO Were.
